MIDAZOLAM – 咪达唑仑15 MG

$128.00$285.00

Therapeutic indications
Short-term insomnia therapy.
Benzodiazepines are indicated only in severe sleep disorders that inhibit patient functioning and lead to extreme agitation.
Patient preparation (premedication) for surgical or diagnostic procedures.

 

咪达唑仑 又称“速眠安” “ 力月西  ”  主要用为治疗急性发作、中度至重度的失眠,及进行医疗程序前之导引镇静及失忆的安眠作用、作用时间约二至五小时。为一种镇静安眠药、属苯二氮平类镇静剂,是一种短效镇静剂。会使人产生睡意,降低焦虑,不易形成新的记忆。也被使用在癫痫治疗上。 此药可口服、静脉注射、肌肉注射、喷入鼻腔、或是借由口腔黏膜吸收。

规格:30片一盒

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$128.00
$218.00

33 in stock

$285.00
Category: Tag: Product ID: 3752

Description

Description

FLORMIDAL DESCRIPTION
Flormidal also contains Flormidal 1 mg, benzyl alcohol 1% v/v as preservative and water for injection.

Flormidal is a short-acting, water soluble benzodiazepine used as a sedative and anesthetic agent. Because of its water solubility, it is well tolerated locally at the sites of IV or IM injection. Another notable feature of Flormidal is the good cardiovascular stability associated with its use. Flormidal is an imidazobendiazepine. It is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4) benzodiazepine. The empirical formula of Flormidal is C18H13CIFN3 and its molecular weight is 325.8.

FLORMIDAL DOSAGE

Tablet: Treatment should be as short as possible. Generally, the duration of treatment varies from a few days to a maximum of 2 weeks. The tapering off process should be tailored to the individual.

In certain cases, extension beyond the maximum treatment period may be necessary; if so, it should not take place without re-evaluation of the patient’s status. Flormidal should be taken just before going to bed, and swallowed whole with fluid.

Standard Dosage: Adults: Dosage Range: 7.5-15 mg.

Elderly and Debilitated Patients: Recommended Dose: 7.5 mg.

Treatment should be started with the lowest recommended dose. The maximum dose should not be exceeded because of the increased risk of unacceptable CNS adverse effects.

Special Dosage Instructions: Patients with Impaired Liver Function: Recommended Dose: 7.5 mg. Flormidal can be taken at any time of the day, provided the patient is subsequently assured of at least 7-8 hrs undisturbed sleep.

If the patient concomitantly receives cimetidine, erythromycin, diltiazem, verapamil, ketoconazole and itraconazole, see Special Dosing Instructions under Interactions.

Premedication: In premedication, Flormidal tablet should be given 30-60 min before the procedure, unless the parenteral route is preferred.

Ampoule: Flormidal is a potent sedative agent which requires slow administration and individualization of dosage.

The dose should be individualized and titrated to the desired state of sedation according to the clinical need, physical status, age and concomitant medication.

In adults >60 years, debilitated or chronically ill patients, the dose should be determined with caution, the special factors relating to each patient being taken into consideration.

IV Conscious Sedation: The IV injection of Flormidal should be given slowly at a rate of approximately 1 mg in 30 sec. The drug takes effect in about 2 min after the injection has been given.

In adults <60 years, the initial dose is 2.5 mg given 5-10 min before the beginning of the procedure.

Further doses of 1 mg may be given as necessary.

A total dose >5 mg is usually not necessary. In adults >60 years, debilitated or chronically ill patients, the initial dose must be reduced to 1-1.5 mg and given 5-10 min before the beginning of the procedure.

Further doses of 0.5-1 mg may be given as necessary. A total dose >3.5 mg is usually not necessary.

Anesthesia: Premedication: Premedication with Flormidal given shortly before a procedure does produce sedation (induction of sleepiness or drowsiness and relief of apprehension) and preoperative impairment of memory.

Flormidal can also be administered in combination with anticholinergics.

The premedication is usually administered 20-60 min before induction of anesthesia.

IM Administration: In adults <60 years, the dose of Flormidal ranges from 0.07-0.1 mg/kg according to the general condition of the patient.

The usual dose is 5 mg.

In adults >60 years, debilitated or chronically ill, the dose range is from 0.025-0.05 mg/kg.

The usual dose is 2-3 mg.

In children between 1 and 15 years, proportionally higher doses are required than in adults in relation to body weight. The dose range from 0.08-0.2 mg/kg body weight has been shown to be effective and safe.

Flormidal should be administered deep into a large muscle mass 30-60 min prior to the induction of anesthesia.

Induction: The desired level of anesthesia is reached by stepwise titration.

The IV induction dose of Flormidal should be given slowly in increments.

Each increment of not more than 5 mg should be injected over 20-30 sec allowing 2 min between successive increments.

In premedicated adults <60 years, the dose can range from 0.15-0.2 mg/kg but a total dose >15 mg is usually not necessary.

In non-premedicated adults <60 years, the dose may be higher (0.3-0.35 mg/kg body weight), but a total dose >20 mg is usually not necessary.

In adults >60 years, debilitated or chronically ill patients, lower doses will be required.

 

药物信息

Flormidal是一种短效的水溶性苯二氮卓类药物,用作镇静剂和麻醉剂。由于它具有水溶性,因此在IV或IM注射部位具有良好的局部耐受性。Flormidal的另一个显着特点是其使用具有良好的心血管稳定性

治疗适应症

短期失眠治疗。

苯二氮卓类药物仅在严重的睡眠障碍中使用,这会妨碍患者的机能并导致严重的焦虑。

准备患者(用药)以进行外科手术或诊断程序。

剂量和给药方法

仅在仔细考虑适应症后,才应使用苯二氮卓类药物,并应尽可能短地使用,以免上瘾。通常,治疗持续几天至最多两个星期。不应突然停止治疗,应针对每位患者量身定制戒断药物。如果需要延长治疗时间(超过两周),则必须对患者进行监护。

如果有必要将治疗延长两周以上,则需要对患者的状况进行初步的重新评估。由于起效迅速,因此在就寝前立即服用咪达唑仑片剂即可。咪达唑仑片可以在一天中的任何时间服用,为患者提供至少7-8个小时的无干扰睡眠。

标准剂量咪达唑仑的标准剂量为7.5 mg至15 mg。

治疗应以最低推荐剂量开始。由于增加的中枢神经系统副作用(包括临床上显着的心血管和呼吸系统抑制)风险,不应超过最大推荐剂量。

服药前

在预用药中,在计划的干预之前30-60分钟使用药物。

具体剂量

老年人和/或精疲力竭的患者

对于年老和/或精疲力竭的患者,推荐剂量为7.5 mg。在老年患者中,咪达唑仑具有更明显的镇静作用,因此这些人可能会出现更高的心血管和呼吸抑制风险。在这些患者中,应格外谨慎地使用药物,必要时可考虑降低剂量。

肝功能受损的患者

对于肝功能受损的患者,推荐剂量为7.5 mg,必须非常小心地使用该药物。如果需要,可以考虑使用较低的剂量。

肾功能受损的患者

在患有严重肾功能不全的患者中,咪达唑仑的主要代谢产物1′-羟基咪唑并列葡糖苷酸可能会积聚,导致更严重,更长时间的镇静作用,可能导致呼吸系统和心血管系统的临床显着下降。因此,在这些患者中应谨慎使用咪达唑仑。建议剂量为7.5 mg,如有必要,可以考虑使用更低的剂量。

用法用量

剂量
一般人群
应用本品治疗通常应使用最低有效剂量,不得超过最大治疗剂量。
成人常用剂量 : 15 mg/片/日。
本品应在临睡前或上床后服用。
特殊人群
老年人
老年患者或肝功能不全的患者 :剂量应减半即为7.5 mg。
每日剂量不得超过15 mg。
规格:30片一盒

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